Nebivolol hydrochloride

Product Name: Nebivolol hydrochloride
CAS No.: 152520-56-4
Chemical Name: Nebivolol hydrochloride
Synonyms: CS-496;D06622;R-67555;Nebilox;Nebilet;Lobivon;Bystolic;Nebivolo;Narbivolol;NEBIVOLOL HC
CBNumber: CB9649567
Molecular Formula: C22H26ClF2NO4
Formula Weight: 441.9
MOL File: 152520-56-4.mol

More

Less

Nebivolol hydrochloride Property

Melting point:: 220-222°C
storage temp.: room temp
solubility: DMSO: ≥20mg/mL
form: powder
color: white to off-white
Merck: 14,6432

More

Less

Safety

Hazard Codes: Xn,N
Risk Statements: 22-50/53
Safety Statements: 60-61
RIDADR: 3077
WGK Germany: 3
HS Code: 29322090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N1915
Product name: Nebivolol hydrochloride
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $82.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1457833
Product name: Nebivolol hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 150mg
Price: $2590
Updated: 2024/03/01

TCI Chemical

Product number: N0954
Product name: Nebivolol Hydrochloride
Purity: >98.0%(HPLC)
Packaging: 20mg
Price: $71
Updated: 2024/03/01

TCI Chemical

Product number: N0954
Product name: Nebivolol Hydrochloride
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $212
Updated: 2024/03/01

Cayman Chemical

Product number: 23660
Product name: Nebivolol (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

More

Less

Nebivolol hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Powder

Uses

A ?-Adrenergic blocker. Used as an antihypertensive

Uses

Nebivolol Hydrochloride is a highly selective β1-adrenoceptor antagonist.

Uses

Nebivolol selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM

Definition

ChEBI: (R,S,S,S)-nebivolol hydrochloride is a hydrochloride obtained by reaction of (R,S,S,S)-nebivolol with one equivalent of hydrochloric acid. It contains a (R,S,S,S)-nebivolol(1+). It is an enantiomer of a (S,R,R,R)-nebivolol hydrochloride.

Biological Activity

Highly selective β 1 -adrenoceptor antagonist (K i values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at β 1 , 5-HT 1A , β 2 , 5-HT 2 , α 1 , H 1 and D 2 receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC 50 = 11.36 μ M in renal arteries) and displays antihypertensive activity in vivo .

Biochem/physiol Actions

Nebivolol hydrochloride (NEB) is used as a racemic mixture for clinical studies. It stabilizes membrane and possesses intrinsic sympathomimetic functionality. Nebivolol interaction with π-acceptors (2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), 2,4-dinitrophenol (DNP) and 2,4,6-trinitrophenol (picric acid; PA)) is useful in the spectrophotometric detection methods.

storage

Desiccate at RT

Nebivolol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Nebivolol hydrochloride Suppliers

Americas 1 Argentina 1 Australia 1 Austria 1 Belgium 1 Canada 3 China 229 China Hong Kong 1 Czech Republic 1 Europe 1 France 3 Germany 5 Greece 1 India 99 Italy 3 Japan 2 Jordan 1 South Korea 1 United Arab Emirates 1 United Kingdom 7 United States 36 Global 399

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2127
Advantage: 70

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14059
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Standardpharm Co. Ltd.

Tel: 86-714-3992388
Email: overseasales1@yongstandards.com
Country: United States
ProdList: 14336
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

More

Less

View Lastest Price from Nebivolol hydrochloride manufacturers

Sigma Audley

Product: Nebivolol hydrochloride 152520-56-4
Price: US $35.00-25.00/kg
Min. Order: 1kg
Purity: 99.8%
Supply Ability: 200tons/year
Release date: 2024-03-15

Shaanxi Dideu Medichem Co. Ltd

Product: Nebivolol hydrochloride 152520-56-4
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99%
Supply Ability: 2000tons
Release date: 2019-12-27

Wuhan Senwayer Century Chemical Co.,Ltd

Product: Nebivolol hydrochloride 152520-56-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 TONS
Release date: 2022-11-09

152520-56-4, Nebivolol hydrochlorideRelated Search:

Carteolol hydrochloride Topotecan hydrochloride Nebivolol Esmolol Tetrahydro-4H-pyran-4-one Tetrahydropyran Metoprolol Atenolol 1-Hydroxyethylidene-1,1-diphosphonic acid Nebivolol Propanolol Bisoprolol Propranolol hydrochloride 4-Ethyl-5-fluoro-6-hydroxypyrimidine Florfenicol AROTINOLOL HCL Esmolol hydrochloride Methylene Blue

Narbivolol

rel-(aR,a′R,2R,2′S)-a,a′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride

Nebivolol hydrochloride, >=98%

RAC NEBIVOLOL, HYDROCHLORIDE

a,a(Iminodimethylene)bis[6-fluoro-2-chromanmethanol] Hydrochloride

Lobivon

Nebilet

Nebilox

R-67555

NEBIVOLOLHYDROCHLORIDE(SUBJECTTOPATENTFREE)

a,a'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride

Nebivolol hydrochloride

NEBIVOLOL HC

R 065824 hydrochloride

CS-496

(169293-50-9) nebivolol hydrochloride

a,a’-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]

(aR,a,2R,2)-rel-a,a[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]

alpha,alpha'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride

D06622

Nebivolol hydrochloride (usan)

(±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)

Nebivolol (Bystolic)

Nebivalate HCl

Bystolic

2H-1-Benzopyran-2-methanol, α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride, [2R*[R*[R*(S*)]]]-(±)-

Nebivolol hydrochloride, 98%, a selective β1 antagonist

NebivololHydrochloride&gt

Nebivolol reference substance

Nebivolol hydrochloride USP/EP/BP

Nebivolol hydrochlorider

Nebivolol hydrochloride Impurities

Nebivolo

Nebivolol Hcl- IP

(±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)

Nebivolol HCl (R 065824)

R-Nebivolol D4 HCl

Nebivolol HydrochlorideQ: What is Nebivolol Hydrochloride Q: What is the CAS Number of Nebivolol Hydrochloride Q: What is the storage condition of Nebivolol Hydrochloride

TIANFU CHEM--Nebivolol hydrochloride

Nebivolol Hydrochloride (1457833)

2H-1-Benzopyran-2-methanol, α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride (1:1), (αR,α'R,2R,2'S)-rel-

(αR,α'R,2R,2'S)-rel-α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-Benzopyran-2-methanol hydrochloride (1:1)

Nebivolol hydrochloride (R-65824)

152520-56-4

C22H26ClF2NO4

C22H25F2NO4HCl

C22H25F2NO4ClH

C22H23O4F2NHCL

R-67145

API

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

152520-56-4